Clobenzorex

ECDD Technical summary
Clobenzorex, chemically (+)-V-[(2-chlorphenylmethyl]-amethylbenzeneethanamine, is a centrally acting anorectic. The drug is rapidly absorbed and excreted in the urine, mainly in the glucuronide form. It is partially metabolized to amphetamine. No data are available concerning its dependence potential in either animals or man and only a few cases of abuse have been reported. No information is available on the therapeutic efficacy of clobenzorex, but it is marketed in a number of countries. There are very few reports of illicit trafficking in the substance. In summary, there is no evidence, except for its structural resemblance to amphetamine and the possibility that it could be metabolized to amphetamine, that clobenzorex has a pharmacological profile or dependence potential similar to substances already controlled under the Convention on Psychotropic Substances. Thus, the Expert Committee considered that it was not in a position to make any recommendation until more information is available about the substance. In addition, since no significant public health problems associated with the use or abuse of clobenzorex have been reported, no recommendation for urgent control seemed necessary.